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KMID : 0389420030110010025
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Korean Journal of Stress Research
2003 Volume.11 No. 1 p.25 ~ p.38
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The Effects of Koamsimsinhwan without Chinnabaris of Morris Water Maze Test and the level of tyrosine hydroxylase in VTA in Chronic Mild Stress(CMS)-treated Rats
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Kim Jong-Chan
Kim Jong-Woo
Whang Wei-Wan
Kim Hyun-Ju
Kim Eun-Joo
Kim Hyun-Taek
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Abstract
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This study was performed to evaluate the effects of Koamsimsinhwan without Cinaabaris on Morris Water Maze and level of tyrosine hydroxylase in VTA in the Chronic Mild Stress(CMS)-treated rats. Rats of trial group were exposed to chronic mild unpredictable stress for 4 weeks. These CMS-treated rats were stratified into Koamsimsinhwan without Cinaabaris group and vehicle group. And there were control rats excluding both CMS and Koamsimsinhwan without Cinaabaris. Morris water maze test was executed and the level of tyrosine hydroxylase in VTA was measured after 4 weeks-treatment of CMS. The results were as follows: 1. In Morris water maze test, the escape latency of CMS-vehicle group was significantly longer than those of the two groups in the 1st training session(p<.05). 2. The levels of tyrosine hydroxylase in VTA after CMS treatment showed significant differences among three groups: CMS-vehicle > CMS-drug > Normal(p<.05). These results suggest that Koamsimsinhwan without Cinaabaris may have preventive effect on the learning impairment and suppressive effect on the increase of the level of tyrosine hydroxylase in VTA induced by CMS treatment.
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KEYWORD
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Depression, Chronic mild stress model, herb, behavioral test, tyrosine hydroxylase level
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